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Beautifully shot and soundtracked, rife with symbolism, and starring a nude Isabella Rossellini, the film, about the adventures of a young man who finds a severed human ear in a field, earned him his second Oscar nomination for Best Director and is frequently ranked among the top one hundred films of all time

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Previous meta-analyses (6769) and systematic review (70) indicated consistent findings of U-shaped association, meaning that light and moderate alcohol consumption were associated with reduced diabetes risk but heavy drinking increased the risk of diabetes

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